1-beta-D-Glucosylsphingadienine (d18:2 (4E,8E)) [114200-59-8]

TargetMol Chemicals

1-beta-D-Glucosylsphingadienine (d18:2 (4E,8E)) [114200-59-8]

16

Chemical

Research Use Only

1-bèta-D-Glucosylsphingadienine (d18:2 (4E,8E))

C24H45NO7

459.624

1-beta-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 microM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gauchers disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-beta-D-glucosylsphingadienine isolated from plants.

3 years

CCCCCCCCCC=CCCC=CC(O)C(N)COC1OC(CO)C(O)C(O)C1O - w:14.14,10.10 -

-20°C

12352200