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10-Methoxy-canthin-6-one

Research Use Only
HY-169067
MedChem Express
Molecular Weight250.25
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    10-Methoxy-canthin-6-one
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C15H10N2O2
  • Molecular Weight
    250.25
  • Scientific Description
    0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research[1].
  • SMILES
    O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34
  • UNSPSC
    12352200