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12-Hydroxynevirapine

HY-148642
MedChem Express
CAS Number133627-24-4
DownloadMSDS
Product group Chemicals
Molecular Weight282.30
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Overview

  • Supplier
    MedChem Express
  • Product Name
    12-Hydroxynevirapine [133627-24-4]
  • Delivery Days Customer
    5
  • CAS Number
    133627-24-4
  • Certification
    Research Use Only
  • Molecular Formula
    C15H14N4O2
  • Molecular Weight
    282.30
  • Scientific Description
    12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine[1][2].
  • SMILES
    O=C1NC2=C(CO)C=CN=C2N(C3CC3)C4=NC=CC=C14
  • UNSPSC
    12352200

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