12R-LOX-IN-1

MedChem Express

12R-LOX-IN-1

14

Research Use Only

C15H11NO2

237.25

12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 microM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-alpha and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].

OC1=CC=C(N=C(C2=CC=CC=C2O)C=C3)C3=C1

12352200