(+/-)14(15)-EET

Biorbyt

(+/-)14(15)-EET [197508-62-6]

10

197508-62-6

Research Use Only

98.00%

C20H32O3

320.473

(+/-)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 microM.[3] (+/-)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion.[5]

CCCCCC1OC1C\C=C/C\C=C/C\C=C/CCCC(O)=O

-20°C

12352200