15 deoxy Delta 12,14 Prostaglandin J2 antibody

GeneTex

15 deoxy Delta 12,14 Prostaglandin J2 antibody

9

This antibody detects Prostaglandin J2 (25.3 %), Prostaglandin D2 (13.13 %), D12-Prostaglandin J2 (8.89 %) and 9a,11b-Prostaglandin F2 alpha (6.93 %).

Working dilutions are best determined by the end user.

ELISA, RadioImmunoAssay

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Rabbit

IgG

15-deoxy-Delta12,14-Prostaglandin J2 (15-d-PGJ2) is one of the ultimate dehydration products of PGD2, formed via the intermediate Delta12-PGJ2. 15-d-PGJ2 is physiologically present in body fluids at concentration of 10-12 to 10-9 M, but increases dramatically under stress such as infection and inflammation. 15-d-PGJ2 exerts both pro- and anti-inflammatory effects in a cell-type and concentration-dependent manner, with many of these effects mediated via binding to the gamma isoform of the peroxisome proliferators-activated receptor (PPAR-gamma). 15-d-PGJ2 appears to induce HO-1 expression by a PPAR-gamma-independent mechanism mediated by the generation of reactive oxygen species (ROS).

Other Species

-20°C or -80°C,2°C to 8°C

12352203