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ProductsBack/1,5-Isoquinolinediol [5154-02-9]
Chemical Structure
Chemical Structure
Chemical Structure

1,5-Isoquinolinediol [5154-02-9]

Research Use Only
AG-CR1-0024
AdipoGen Life Sciences
CAS Number5154-02-9
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight161.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    1,5-Isoquinolinediol [5154-02-9]
  • Delivery Days Customer
    10
  • CAS Number
    5154-02-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C9H7NO2
  • Molecular Weight
    161.2
  • Scientific Description
    Chemical. CAS: 5154-02-9. Formula: C9H7NO2. MW: 161.2. PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination. - PARP-1 inhibitor [1]. Neuroprotectant [2]. Blocks nitric oxide-induced neuronal toxicity [2]. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor [3]. Stimulates homologous recombination [4].
  • SMILES
    OC1=CC=CC2=C(O)N=CC=C12
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992)
  • Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994)
  • Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006)
  • 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts: A. Semionov, et al.; Biochem. Cell Biol. 81, 17 (2003)