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(±)16(17)-EpDPA

T37235
TargetMol Chemicals
CAS Number155073-46-4
Product group Chemicals
Molecular Weight344.495
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    (±)16(17)-EpDPA
  • Delivery Days Customer
    1001
  • CAS Number
    155073-46-4
  • Category Supplier
    Chemical
  • Chemical Name
    (±)16(17)-EpDPA
  • Molecular Formula
    C22H32O3
  • Molecular Weight
    344.495
  • Scientific Description
    EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.[4]
  • Shelf life instruction
    3 years
  • SMILES
    CC\C=C/C[C@H]1O[C@H]1C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O
  • Storage Instruction
    -20°
  • UNSPSC
    12352200