17(R)-Resolvin D1 methyl ester [937738-64-2]

TargetMol Chemicals

17(R)-Resolvin D1 methyl ester [937738-64-2]

16

Chemical

Research Use Only

17(R)-Resolvin D1 methyl ester

C23H34O5

390.5

17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that equivalently inhibits human polymorphonuclear leukocyte migration across the endothelium (EC50= ~30 nM), a precursor to acute inflammation. Unlike RvD1, it resists rapid degradation by eicosanoid oxidoreductases. In a mouse peritonitis model, 17(R)-RvD1 dose-dependently reduces leukocyte infiltration, achieving up to a 35% decrease with a 100 ng dose. Additionally, its methyl ester derivative, designed to enhance its pharmacokinetic and distribution properties as a more lipophilic prodrug, can be converted back into the active acid form by intracellular esterases.

3 years

[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@@H](C/C=C\CC)O)O)(C/C=C\CCC(OC)=O)O

-20°C

12352200