2-Bromo-4'-hydroxyacetophenone
T7084
CAS Number2491-38-5
Product group Chemicals
Molecular Weight215.04
Overview
- SupplierTargetMol Chemicals
- Product Name2-Bromo-4'-hydroxyacetophenone
- Delivery Days Customer4
- CAS Number2491-38-5
- Category SupplierChemical
- Chemical Name2-Bromo-4'-hydroxyacetophenone
- Molecular FormulaC8H7BrO2
- Molecular Weight215.04
- Scientific Description2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 uM and PTP1B with a Ki value of 42 uM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].
- Shelf life instruction3 years
- SMILESC(CBr)(=O)C1=CC=C(O)C=C1
- Storage Instruction-20°
- UNSPSC12352200
References
- Heneberg, P. Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. Current Medicinal Chemistry 16(6), 706-733 (2009).