2-Fluoro-2-Deoxyadenosine [64183-27-3]

TargetMol Chemicals

2-Fluoro-2-Deoxyadenosine [64183-27-3]

4

64183-27-3

Chemical

Research Use Only

2'-Fluoro-2'-Deoxyadenosine

C10H12FN5O3

269.23

2-Fluoro-2-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2-Fluoro-2-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2-Fluoro-2-Deoxyadenosine can be used to synthesize 2-deoxy-2-fluoromodified oligonucleotides that can hybridize to RNA.

3 years

Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F

-20°C

12352200