2-Fluoro-5-O-DMT-2-deoxyinosine-3-CE-phosphoramidite

MedChem Express

2-Fluoro-5-O-DMT-2-deoxyinosine-3-CE-phosphoramidite

10

Research Use Only

98.81

C40H46FN6O7P

772.80

2-Fluoro-5-O-DMT-2-deoxyinosine-3-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia [1] [2] .

COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N5C(NC=NC6=O)=C6N=C5)O4

2°C to 8°C

12352200