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ProductsBack/22-NHC . hydrochloride [360068-87-7]
Chemical Structure
Chemical Structure
Chemical Structure

22-NHC . hydrochloride [360068-87-7]

Research Use Only
AG-CR1-3523
AdipoGen Life Sciences
CAS Number360068-87-7
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight387.6 . 36.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    22-NHC . hydrochloride [360068-87-7, 3915-24-0]
  • Delivery Days Customer
    10
  • CAS Number
    360068-87-7
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C26H45NO . HCl
  • Molecular Weight
    387.6 . 36.5
  • Scientific Description
    Aza-steroid [1]. Hedgehog signaling inhibitor [1]. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo) [1]. For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html . - Chemical. CAS: 360068-87-7 or 3915-24-0 (free base). Formula: C26H45NO . HCl. MW: 387.6 . 36.5. Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html .
  • SMILES
    [Cl-].[H][C@@]12CC[C@H]([C@H](C)[NH2+]CCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling: D. Nedelcu, et al.; Nat. Chem. Biol. 9, 557 (2013)