2,3-dinor-8-iso Prostaglandin F2alpha [221664-05-7]

TargetMol Chemicals

2,3-dinor-8-iso Prostaglandin F2alpha [221664-05-7]

16

221664-05-7

Chemical

Research Use Only

2,3-dinor-8-iso Prostaglandin F2alfa

C18H30O5

326.4

8-isoProstaglandin F2alpha (8-isoPGF2alpha; 8-isoprostane) is a byproduct of non-specific lipid peroxidation, resembling prostaglandin in structure. In humans and rats, its metabolite, 12,3-dinor-8-isoPGF2alpha, is formed following exogenous administration of 8-isoPGF2alpha, which is converted to 2,3-dinor-8-isoPGF1alpha and 2,3-dinor-8-isoPGF2alpha. Additionally, rat hepatocytes can further break down 8-isoPGF2alpha into a beta-oxidation product, 2,3,4,5-tetranor-8-isoPGF2alpha. The metabolite, 2,3-dinor-8-isoPGF2alpha, is normally found in human urine at concentrations of 200-300 pg/ml. Its levels rise in conditions associated with oxidative stress, such as smoking, demonstrating a correlation with the concentration of its precursor, 8-isoPGF2alpha.

3 years

C(/C=C\CC(O)=O)[C@H]1[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C[C@@H]1O

-20°C

12352200