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ProductsBack/(25S)-delta7-Dafachronic acid [UPF-1404]
Chemical Structure
Chemical Structure
Chemical Structure

(25S)-delta7-Dafachronic acid [UPF-1404]

Research Use Only
AG-CN2-0014
AdipoGen Life Sciences
CAS Number949004-12-0
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight414.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    (25S)-Delta7-Dafachronic acid [949004-12-0]
  • Delivery Days Customer
    10
  • CAS Number
    949004-12-0
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C27H42O3
  • Molecular Weight
    414.6
  • Scientific Description
    Chemical. CAS: 949004-12-0. Formula: C27H42O3. MW: 414.6. Ligand of DAF-12, an orphan nuclear receptor, that regulates dauer diapause, reproductive development, fat metabolism, and life span (life cycle) in parasitic nematodes. Sterol-derived hormone. Blocks formation of infective larvae in several parasitic nematodes. Inhibits the dauer-promoting activity of DAF-12. Supports the reproductive development. - Ligand of DAF-12, an orphan nuclear receptor, that regulates dauer diapause, reproductive development, fat metabolism, and life span (life cycle) in parasitic nematodes [1, 2, 3]. Sterol-derived hormone. Blocks formation of infective larvae in several parasitic nematodes [4, 5]. Inhibits the dauer-promoting activity of DAF-12 [4, 5]. Supports the reproductive development [4, 5].
  • SMILES
    C[C@H](CCC[C@H](C)C(O)=O)[C@H]1CCC2C3=CCC4CC(=O)CC[C@]4(C)C3CC[C@]12C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans: D.L. Motola, et al.; Cell 124, 1209 (2006)
  • A Potential Biochemical Mechanism Underlying the Influence of Sterol Deprivation Stress on Caenorhabditis elegans: M.C. Cheong, et al.; JBC 286, 7248 (2011)
  • Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan: K.J. Dumas, et al.; Dev. Biol. 340, 605 (2010)
  • A Conserved Endocrine Mechanism Controls the Formation of Dauer and Infective Larvae in Nematodes: A. Ogawa, et al.; Curr. Biol. 19, 67 (2009)
  • Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes: Z. Wang, et al.; PNAS 106, 9138 (2009)
  • Indicted: Worms Caught using Steroids: R.B. Beckstead & C.S. Thummel; Cell 124, 1137 (2006) Review