Chemical Structure
Chemical Structure
3-Aminoisobutyric acid [144-90-1, 214139-20-5]
AG-CR1-3596
Estimated Purity>98%
Product group Chemicals
Molecular Weight103.1 . 18.0
Overview
- SupplierAdipoGen Life Sciences
- Product Name3-Aminoisobutyric acid [144-90-1, 214139-20-5]
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity>98%
- Hazard InformationNon-hazardous
- Molecular FormulaC4H9NO2 . H2O
- Molecular Weight103.1 . 18.0
- Scientific DescriptionCatabolite of thymine [1-4]. Precursor for 3-Hydroxyisobutyric acid synthesis [3]. Small molecule myokine. Browning inducer of white adipose tissue (WAT) into brown adipose tissue (BAT) [9, 10]. PGC-1alpha-mediated and exercise-triggered nonadrenergic activator of the thermogenic program in WAT. Increases the expression of brown adipocyte-specific genes (browning) in white adipocytes and beta-oxidation in hepatocytes through a PPARalpha-mediated mechanism [9, 10]. Induces a brown adipose-like phenotype in human pluripotent stem cells and improves glucose homeostasis [9, 10]. Enhances fatty acid oxidation and reduces body weight in mice through an increased production of leptin by the white adipose tissue (WAT) [5-7]. Inhibits Agxt2-mediated metabolism of dimethylarginines [8]. Partial agonist of the glycine receptor (GlyR) [4]. - Chemical. CAS: 214139-20-5 and 144-90-1 (anhydrous). Formula: C4H9NO2 . H2O. MW: 103.1 . 18.0. Catabolite of thymine. Precursor for 3-Hydroxyisobutyric acid synthesis. Small molecule myokine. Browning inducer of white adipose tissue (WAT) into brown adipose tissue (BAT). PGC-1alpha-mediated and exercise-triggered nonadrenergic activator of the thermogenic program in WAT. Increases the expression of brown adipocyte-specific genes (browning) in white adipocytes and beta-oxidation in hepatocytes through a PPARalpha-mediated mechanism. Induces a brown adipose-like phenotype in human pluripotent stem cells and improves glucose homeostasis. Enhances fatty acid oxidation and reduces body weight in mice through an increased production of leptin by the white adipose tissue (WAT). Inhibits Agxt2-mediated metabolism of dimethylarginines. Partial agonist of the glycine receptor (GlyR).
- SMILESCC(CN)C(O)=O
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200
References
- beta-Aminoisobutyric acid (alpha-methyl-beta-alanine); a new amino-acid obtained from human urine: H.R. Crumpler, et al.; Nature 167, 307 (1951)
- beta-aminoisobutyric acid, a new probe for the metabolism of DNA and RNA in normal and tumorous tissue: H.R. Nielsen, et al.; Cancer Res. 34, 1381 (1974)
- Metabolism of thymine in tumor tissue: the origins of beta-aminoisobutyric acid: B.S. Baliga & E. Borek; Adv. Enzyme Regul. 13, 27 (1975)Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis: S. Landaas; Clin. Chim. Acta 64, 143 (1975)
- Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds: V. Schmieden & H. Betz; Mol. Pharmacol. 48, 919 (1995)
- Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting: C. Maisonneuve, et al.; Antivir. Ther. 9, 801 (2004)
- Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency: K. Begriche, et al.; Obesity (Silver Spring) 16, 2053 (2008)
- Effects of beta-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity: K. Begriche, et al.; Fundam. Clin. Pharmacol. 24, 269 (2010)
- In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice: A. Kittel, et al.; BBRC 430, 84 (2013)
- beta-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors: L.D. Roberts, et al.; Cell Metab. 19, 96 (2014)
- Come on BAIBA light my fire: H.L. Kammon & M. Febbraio; Cell Metab. 19, 1 (2014) (Review)