Chemical Structure
Chemical Structure
3-Methyladenine [5142-23-4]
AG-CR1-3597
Overview
- SupplierAdipoGen Life Sciences
- Product Name3-Methyladenine [5142-23-4]
- Delivery Days Customer10
- CAS Number5142-23-4
- CertificationResearch Use Only
- Estimated Purity>98%
- Molecular FormulaC6H7N5
- Molecular Weight149.2
- Scientific DescriptionChemical. CAS: 5142-23-4. Formula: C6H7N5. MW: 149.2. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Blocks class I, class II and class III PI3Ks, including some downstream targets. Blocks class I PI3K persistently and class III PI3K transiently. Induces autophagy under nutrient-rich conditions and inhibits starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase. Shows some limited Vps34 preference in vitro compared to PtdIns3Kgamma. However, it is typically employed in cellular studies at a concentration of 10 mM, which can inhibit all PtdIns3Ks. Can target other kinases and affect other cellular processes, such as glycogen metabolism, lysosomal acidification, endocytosis and mitochondrial permeability transition. Anticancer compound. Neuroprotective. PKA-activation dependent lipolytic agent. Enhances ATGL-dependent hydrolysis of triacylglycerols. - Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K) [1, 7, 8]. Blocks class I, class II and class III PI3Ks, including some downstream targets [8]. Blocks class I PI3K persistently and class III PI3K transiently [7]. Induces autophagy under nutrient-rich conditions and inhibits starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase [5, 7]. Shows some limited Vps34 preference in vitro compared to PtdIns3Kgamma. However, it is typically employed in cellular studies at a concentration of 10 mM, which can inhibit all PtdIns3Ks [8]. Can target other kinases and affect other cellular processes, such as glycogen metabolism, lysosomal acidification, endocytosis and mitochondrial permeability transition [2-4]. Anticancer compound [6, 10, 12]. Neuroprotective [9, 11]. PKA-activation dependent lipolytic agent. Enhances ATGL-dependent hydrolysis of triacylglycerols [13].
- SMILESCN1C=NC(N)=C2N=CN=C12
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200
References
- 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes: P.O. Seglen & P.B. Gordon; PNAS 79, 1889 (1982)
- 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism: L.H. Caro, et al.; Eur. J. Biochem. 175, 325 (1988)
- 3-Methyladenine inhibits transport from late endosomes to lysosomes in cultured rat and mouse fibroblasts: E.L. Punnonen, et al.; Eur. J. Cell Biol. 65, 14 (1994)
- Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues: L. Xue, et al.; Biochem. Pharmacol. 64, 441 (2002)
- 3-methyladenine inhibits autophagy in tobacco culture cells under sucrose starvation conditions: C. Takatsuka, et al.; Plant Cell Physiol. 45, 265 (2004)
- 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition: S. Ito, et al.; Int. J. Oncol. 31, 261 (2007)
- Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase: Y.T. Wu, et al.; J. Biol. Chem. 285, 10850 (2010)
- Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor: S. Miller, et al.; Autophagy 6, 805 (2010)
- Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy: J.Y. Wang, et al.; J. Neuropathol. Exp. Neurol. 70, 314 (2011)
- Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells: H. Hou, et al.; PLoS One 7, e35665 (2012)