3-O-Demethyl-4-N-demethyl-4-N-acetyl-4-epi-staurosporine

MedChem Express

3-O-Demethyl-4-N-demethyl-4-N-acetyl-4-epi-staurosporine

14

Research Use Only

C28H24N4O4

480.51

3-O-Demethyl-4-N-demethyl-4-N-acetyl-4-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 microM for PKC-alpha, ROCK, ASK1. 3-O-Demethyl-4-N-demethyl-4-N-acetyl-4-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 microM[1].

O=C1C2=C3C(N4C5=C3C=CC=C5)=C6C(C(C=CC=C7)=C7N6[C@]8(C)[C@H](O)[C@@H](NC(C)=O)C[C@@]4([H])O8)=C2CN1

12352200