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ProductsBack/3,3′-Diindolylmethane [1968-05-4]

3,3′-Diindolylmethane [1968-05-4]

Research Use Only
D3232
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 92,00
1 g
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More than 130 suppliers
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    3,3′-Diindolylmethane [1968-05-4]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Soluble in DMSO (200 mg/mL). Insoluble in water.
  • Scientific Description
    Indole found in cruciferous vegetables; AhR agonist.; 3,3'-Diindolymethane, 3,3'-Methylenebis-1H-indole, DIM
  • Storage Instruction
    Ambient
  • UNSPSC
    12352200

References

  • Liu Y, She W, Wang F, et al. 3, 3'-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. Int Immunopharmacol. 2014 Oct 1. [Epub ahead of print]. PMID: 25281898. Rouse M, Rao R, Nagarkatti M, et al. 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways. J Pharmacol Exp Ther. 2014 Aug;350(2):341-52. PMID: 24898268. Wu T, Chen C, Li F, et al. 3,3'-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. Exp Ther Med. 2014 Jun;7(6):1635-1638. PMID: 24926357. Poornima J, Mirunalini S. Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3'-diindolylmethane in high-fat diet-induced C57BL/6J mice. Mol Cell Biochem. 2014 Jan;385(1-2):7-15. PMID: 24072613. Zhang Z, Gao Z, Hu W, et al. 3,3'-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression. Br J Pharmacol. 2013 Oct;170(3):649-60. PMID: 23902531. Chen C, Chen SM, Xu B, et al. In vivo and in vitro study on the role of 3,3'-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma. Carcinogenesis. 2013 Aug;34(8):1815-21. PMID: 23568953. Beaver LM, Yu TW, Sokolowski EI, et al. 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol. 2012 Sep 15;263(3):345-51. PMID: 22800507. Cho HJ, Seon MR, LLee YM, et al. 3,3’-Diindolylmethane suppresses the inflammatory response to lipopolysacharide in murine macrophages. J Nutr. 2008 Jan;138(1):17-23. PMID: 18156398.