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ProductsBack/3H-1,2-Dithiole-3-thione [534-25-8]

3H-1,2-Dithiole-3-thione [534-25-8]

Research Use Only
D0010
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 147,00
25 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    3H-1,2-Dithiole-3-thione [534-25-8]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Insoluble in water. Soluble in DMSO (≥10 mg/ml).
  • Scientific Description
    Induces activation of Nrf2; inhibits apoptosis in neurons; prevents the formation of DBP-induced DNA adducts.; D3T, 1,2-Dithiol-3-thione
  • Storage Instruction
    Ambient
  • UNSPSC
    12352200

References

  • Jia J, Xiao Y, Wang W, et al. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress. Neurochem Int. 2013 Jun;62(8):1072-8. PMID: 23587562. Pazdro R, Burgess JR. The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells. Exp Diabetes Res. 2012;2012:137607. PMID: 22675339. Dong J, Yan D, Chen SY. Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells. PLoS One. 2011 Feb 3;6(2):e16845. PMID: 21304811. Kwak MK, Egner PA, Dolan PM, et al. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res. 2001 Sep 1;480-481:305-15. PMID: 11506823. Pillon NJ, Croze ML, Vella RE, et al. The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress. Endocrinology. 2012 May;153(5):2099-2111. PMID: 22396448.