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Chemical Structure
Chemical Structure
Chemical Structure

4-Methylumbelliferone [90-33-5]

Research Use Only
CDX-M0007
Chemodex
CAS Number90-33-5
Product group Chemicals
Estimated Purity>95%
Molecular Weight176.17
Price on request
Packing Size
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Overview

  • Supplier
    Chemodex
  • Product Name
    4-Methylumbelliferone [90-33-5]
  • Delivery Days Customer
    10
  • CAS Number
    90-33-5
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C10H8O3
  • Molecular Weight
    176.17
  • Scientific Description
    4-Methylumbelliferone (4-MU) is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer. Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 (plateau above pH10). The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data: lambdaex=360nm; lambdaem=448nm; pH > 9. 4-Methylumbelliferone is an indicator also used in the determination of nitric acid and in 4-MU-O-substrates for the kinetic investigation of enzyme activity. - Chemical. CAS: 90-33-5. Formula: C10H8O3. MW: 176.17. 4-Methylumbelliferone (4-MU) is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer. Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 (plateau above pH10). The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data: lambdaex=360nm; lambdaem=448nm; pH > 9. 4-Methylumbelliferone is an indicator also used in the determination of nitric acid and in 4-MU-O-substrates for the kinetic investigation of enzyme activity.
  • SMILES
    OC1=CC=C2C(OC(C=C2C)=O)=C1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200