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ProductsBack/4alpha-Phorbol 12-myristate 13-acetate [63597-44-4]
Chemical Structure
Chemical Structure
Chemical Structure

4alpha-Phorbol 12-myristate 13-acetate [63597-44-4]

Research Use Only
AG-CN2-0082
AdipoGen Life Sciences
Estimated Purity>98%
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Product group Chemicals
Molecular Weight616.8
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    4alpha-Phorbol 12-myristate 13-acetate [63597-44-4]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C36H56O8
  • Molecular Weight
    616.8
  • Scientific Description
    Chemical. CAS: 63597-44-4. Formula: C36H56O8. MW: 616.8. Semi-synthetic. Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010). Might be a reasonable PKC-independent TRPV4 channels agonist. - Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010) [1-6]. Might be a reasonable PKC-independent TRPV4 channels agonist [5].
  • SMILES
    [H][C@]12[C@]3([H])C=C(CO)C[C@@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCCCCCC)[C@@]1(OC(C)=O)C2(C)C
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin: B.L. Van Duuren et al.; Cancer Res. 39, 2644 (1979)
  • Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation: M. Thivierge, et al.; J. Immunol. 157, 4681 (1996)
  • Integrin ligation and PKC activation are required for migration of colon carcinoma cells: V. Rigot, et al.; J. Cell Sci. 111, 3119 (1998)
  • Activated protein kinase C isoforms target to cardiomyocyte caveolae: stimulation of local protein phosphorylation: V.O. Rybin, et al.; Circ. Res. 84, 980 (1999)
  • Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4: F. Xu, et al.; Br. J. Pharmacol. 140, 413 (2003)
  • Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva, et al; Eur. J. Pharmacol. 491, 101 (2004)