5-Azido-5-deoxy-2-O,4-C-methyleneuridine

MedChem Express

5-Azido-5-deoxy-2-O,4-C-methyleneuridine

10

Research Use Only

C10H11N5O5

281.22

5-Azido-5-deoxy-2-O,4-C-methyleneuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5-Azido-5-deoxy-2-O,4-C-methyleneuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O[C@@H]1[C@@]2(CN=[N+]=[N-])O[C@@H](N3C(NC(C=C3)=O)=O)[C@@H]1OC2

41106300