5-Nitro-1-(3-azido-3-deoxy-beta-D-ribofuranosyl)-2(1H)-pyridinone

MedChem Express

5-Nitro-1-(3-azido-3-deoxy-beta-D-ribofuranosyl)-2(1H)-pyridinone

10

Research Use Only

C10H11N5O6

297.22

5-Nitro-1-(3-azido-3-deoxy-beta-D-ribofuranosyl)-2(1H)-pyridinone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5-Nitro-1-(3-azido-3-deoxy-beta-D-ribofuranosyl)-2(1H)-pyridinone is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

OC[C@@H]1[C@@H](N=[N+]=[N-])[C@@H](O)[C@H](N2C(C=CC([N+]([O-])=O)=C2)=O)O1

41106300