(5aS,6R,6aR)-MK-8666

MedChem Express

(5aS,6R,6aR)-MK-8666

9

Research Use Only

C29H31NO6S

521.62

(5aS,6R,6aR)-MK-8666 is a selective GPR40 agonist with activity in promoting fatty acid-induced insulin secretion in pancreatic beta cells and intestinal enteroendocrine cells. (5aS,6R,6aR)-MK-8666 has been studied for the inhibition of type 2 diabetes and has shown significant blood glucose lowering effects. Although (5aS,6R,6aR)-MK-8666 is considered to have potential inhibitory advantages, its development was stopped in Phase I clinical trials due to liver safety issues[1].

OC([C@H]1[C@@]2([H])[C@]1([H])CC3=CC(OCC4=CC(C5=C(C=C(C=C5C)OCCCS(C)(=O)=O)C)=CC=C4)=NC=C32)=O

12352200