6-Chloropurine riboside-5-triphosphate sodium

TargetMol Chemicals

6-Chloropurine riboside-5-triphosphate sodium

999

Chemical

Research Use Only

6-Chloropurine riboside-5'-triphosphate sodium

C10H10ClN4O13P3.4Na

614.54

6-Chloropurine riboside-5-triphosphate serves as both an inhibitor and an activator in biochemical processes. It inhibits the RNA triphosphatase mRNA-capping enzyme subunit beta (Cet1; IC50 = 2 microM for the GTPase activity of the S. cerevisiae enzyme), proving its efficacy against the enzyme responsible for the capping of mRNA molecules. Additionally, it acts as a phosphorylated derivative of 6-chloropurine riboside. This compound also activates the E. coli enzyme aspartate carbamoyltransferase (EC50 = 0.76 mM), demonstrating its versatility in modulating enzyme activities. It is instrumental in the synthesis of cytokinins with anticancer properties and a photoclickable form of ATP, highlighting its applications in biochemical synthesis and potential therapeutic uses.

3 years

O[C@@H]1[C@@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(Cl)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+].[Na+]

-20°C

12352200