6beta-hydroxy Dexamethasone [55879-47-5]

TargetMol Chemicals

6beta-hydroxy Dexamethasone [55879-47-5]

44

55879-47-5

Chemical

Research Use Only

6bèta-hydroxy Dexamethasone

C22H29FO6

408.46

6beta-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6alpha- and 6beta-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

3 years

F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(C[C@@H](O)C=4[C@]2(C)C=CC(=O)C4)[H]

-20°C

12352200