7,8-Dihydroxyflavone Hydrate [38183-03-8]

Chan CB, Tse MC, Liu X, et al. Activation of Muscular TrkB by its Small Molecular Agonist 7,8-Dihydroxyflavone Sex-Dependently Regulates Energy Metabolism in Diet-Induced Obese Mice. 2015 Mar 19;22(3):355-68. PMID: 25754472. Sconce MD, Churchill MJ, Moore C, et al. Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson's disease. Neuroscience. 2015 Apr 2;290:454-71. PMID: 25655214. Lee RH, Shin JC, Kim KH, et al. Apoptotic effects of 7,8-dihydroxyflavone in human oral squamous cancer cells through suppression of Sp1. Oncol Rep. 2015 Feb;33(2):631-8. PMID: 25434704. Wu CH, Hung TH, Chen CC, et al. Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling. PLoS One. 2014 Nov 21;9(11):e113397. PMID: 25415296. Yang YJ, Li YK, Wang W, et al. Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia. Pharmacol Biochem Behav. 2014 Jul;122:30-6. PMID: 24662915. Korkmaz OT, Aytan N, Carreras I, et al. 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis. Neurosci Lett. 2014 Apr 30;566:286-91. PMID: 24637017. Park HY, Park C, Hwang HJ, et al. 7,8-Dihydroxyflavone attenuates the release of pro-inflammatory mediators and cytokines in lipopolysaccharide-stimulated BV2 microglial cells through the suppression of the NF-kappaB and MAPK signaling pathways. Int J Mol Med. 2014 Apr;33(4):1027-34. PMID: 24535427. Ryu MJ, Kang KA, Piao MJ, et al. 7,8-Dihydroxyflavone protects human keratinocytes against oxidative stress-induced cell damage via the ERK and PI3K/Akt-mediated Nrf2/HO-1 signaling pathways. Int J Mol Med. 2014 Apr;33(4):964-70. PMID: 24503931. Castello NA, Nguyen MH, Tran JD, et al. 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. PLoS One. 2014 Mar 10;9(3):e91453. PMID: 24614170.