8-CPT-2Me-cAMP (sodium)

MedChem Express

8-CPT-2Me-cAMP (sodium) [634207-53-7]

10

634207-53-7

Research Use Only

99.58

C17H16ClN5NaO6PS

507.82

8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac) , the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 ( EC 50 = 2.2 microM), but not PKA ( EC 50 > 10 microM) [1] . 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca 2+ release in pancreatic beta-cells in vitro [2] .

NC1=C2C(N([C@H]3[C@@H]([C@@](O4)([H])[C@](COP4(O[Na])=O)([H])O3)OC)C(SC5=CC=C(Cl)C=C5)=N2)=NC=N1

-20°C

12352200