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8-Oxoguanine DNA Glycosylase(CPTC-OGG1-1), CF640R conjugate, 0.1mg/mL [26628-22-8]

8-Oxoguanine DNA Glycosylase(CPTC-OGG1-1), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC402251
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetOGG1
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Overview

  • Supplier
    Biotium
  • Product Name
    8-Oxoguanine DNA Glycosylase(CPTC-OGG1-1), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CPTC-OGG1-1
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID4968
  • Target name
    OGG1
  • Target description
    8-oxoguanine DNA glycosylase
  • Target synonyms
    8-hydroxyguanine DNA glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; HMMH; HOGG1; MUTM; N-glycosylase/DNA lyase; OGG1 type 1f; OGH1
  • Host
    Mouse
  • Isotype
    IgG2c
  • Protein IDO15527
  • Protein Name
    N-glycosylase/DNA lyase
  • Scientific Description
    8-Oxoguanine DNA Glycosylase (OGG1), otherwise known as N-Glycosylase/DNA lyase, is the enzyme responsible for the excision of 8-oxoguanine (8-oxoG), a mutagenic base by-product which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Defects in OGG1 may be a cause of renal cell carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203