(±)8,9-DiHETE

TargetMol Chemicals

(±)8,9-DiHETE

1001

867350-87-6

Chemical

(±)8,9-DiHETE

C20H32O4

336.472

(±)8,9-DiHETE is a major metabolite of the 20:5 omega-3 fatty acid eicosapentaenoic acid .[1] It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases. Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.[2]

3 years

CC\C=C/C\C=C/C\C=C/CC(O)C(O)C\C=C/CCCC(O)=O

-20°

12352200