9-[2-O-Acetyl-3-azido-3-deoxy-5-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine

MedChem Express

9-[2-O-Acetyl-3-azido-3-deoxy-5-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine

10

Research Use Only

9-[2-O-Acetyl-3-azido-3-deoxy-5-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis , etc [1] . 9-[2-O-Acetyl-3-azido-3-deoxy-5-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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