9-Hydroxyellipticin

MedChem Express

9-Hydroxyellipticin

9

51131-85-2

Research Use Only

C17H14N2O

262.31

9-hydroxyellipticine is an inhibitor of Topo II and RyR , exhibiting high affinity for DNA with a P ka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC 50 values of 1.6 microM and 1.2 microM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice [1] .

OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1

12352200