A-1208746

MedChem Express

A-1208746

9

Research Use Only

C45H52N6O7S

821.00

A-1208746 is an inhibitor for MCL-1 , with a K i of 0.454 nM. A-1208746 activates caspase-3/-7 , induces apoptosis in cell H929, and decreases mitochondrial membrane potential. A-1208746 synergies with Navitoclax (HY-10087), and can be used in cancer research [1] .

O=S(N(CC1)CCN1C2=CC=C(OCC3=C(C4=C(N(CCN5CCOCC5)C(C(O)=O)=C6CCCOC7=C(C=CC=C8)C8=CC=C7)C6=CC=C4)C(C)=NN3C)C=C2)(C)=O

12352200