A-443654 [552325-16-3]

AdipoGen Life Sciences

A-443654

10

552325-16-3

Research Use Only

>98%

C24H23N5O

397.5

Chemical. CAS: 552325-16-3. Formula: C24H23N5O. MW: 397.5. Synthetic. Potent and selective Akt inhibitor (Ki=160pmol/L for all three isoforms PKBalpha, PKBbeta and PKBgamma). DYRK1A inhibitor (IC50=10nM). Inhibits other kinases, including PRK2, MSK1 and DYRK3 at low nM range as well. Interferes with mitotic progression by regulating aurora a kinase expression and bipolar spindle formation. It induces G2/M accumulation, defects in centrosome separation and formation of either monopolar arrays or disorganized spindles. Anticancer agent. Apoptosis inducer and chemosensitizing agent. Slows the progression and growth of Akt-dependent tumors. Induces rapid Akt Ser473 phosphorylation independent of mTORC1 inhibition in human cancer cell lines. Activates mTORC2 and reverses long-term memory deficits. - Potent and selective Akt inhibitor (Ki=160pmol/L for all three isoforms PKBalpha, PKBbeta and PKBgamma). DYRK1A inhibitor (IC50=10nM). Inhibits other kinases, including PRK2, MSK1 and DYRK3 at low nM range as well. Interferes with mitotic progression by regulating aurora a kinase expression and bipolar spindle formation. It induces G2/M accumulation, defects in centrosome separation and formation of either monopolar arrays or disorganized spindles. Anticancer agent. Apoptosis inducer and chemosensitizing agent. Slows the progression and growth of Akt-dependent tumors. Induces rapid Akt Ser473 phosphorylation independent of mTORC1 inhibition in human cancer cell lines. Activates mTORC2 and reverses long-term memory deficits.

N[C@@H](CC1=CNC2=C1C=CC=C2)COC3=CC(C4=CC(C(C)=NN5)=C5C=C4)=CN=C3

-20°C,2°C to 8°C

51202000