A947 [2378056-80-3]

TargetMol Chemicals

A947 [2378056-80-3]

999

Chemical

Research Use Only

A947

C61H76N12O7S

1121.4

A947, a potent and selective SMARCA2 proteolysis-targeting chimera (PROTAC) molecule, also acts as a moderately selective SMARCA2 degrader. It exhibits strong binding affinity to the SMARCA2 bromodomain, with a dissociation constant (K d) of 93 nM, making it a valuable tool for cancer research [1].

3 years

CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(cc1)-c1scnc1C)c1cc(no1)N1CCC(CN2CCC(CC2)O[C@H]2C[C@@H](C2)Oc2cc(ccn2)N2C3CCC2CN(C3)c2cc(nnc2N)-c2ccccc2O)CC1

-20°C

12352200