ABAT Polyclonal Antibody

Reddot Biotech

ABAT Polyclonal Antibody

5

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

ABAT

4-aminobutyrate aminotransferase

(S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate transaminase; GABA aminotransferase; GABA transaminase; GABA transferase; GABA-AT; GABAT; gamma-aminobutyrate aminotransferase; gamma-amino-N-butyrate transaminase; NPD009

Rabbit

IgG

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Human, Mouse, Rat

-20°C

12352203