Abeta42-IN-1 free base [2434633-17-5]

TargetMol Chemicals

Abèta42-IN-1 free base

72

2434633-17-5

Chemical

Research Use Only

Abèta42-IN-1 free base

C29H26N4O2

462.54

Abeta42-IN-1 free base (compound 1v), an orally active gamma-secretase modulator with high brain exposure, effectively lowers Abeta42 levels with an IC50 of 0.091 microM, and significantly diminishes brain Abeta42 levels in mice. Given these properties, Abeta42-IN-1 free base represents a potential disease-modifying agent for Alzheimers disease [1].

3 years

CC1=C(N2C(=N1)C(OCC3=CC=C(C=C3)C4=CC=CC=C4)=CC=C2)C=5C=CC(C(NCC)=O)=NC5

-20°C

51202000