ABL1 Polyclonal Antibody

Reddot Biotech

ABL1 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

Abelson tyrosine-protein kinase 1; ABL; ABL protooncogene 1 nonreceptor tyrosine kinase; bcr/abl; bcr/c-abl oncogene protein; BCR-ABL; c-ABL; c-abl oncogene 1, receptor tyrosine kinase; c-ABL1; CHDSKM; JTK7; p150; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; truncated ABL protooncogene 1 nonreceptor tyrosine kinase; tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia viral oncogene homolog 1

Rabbit

IgG

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

Human, Mouse

-20°C

12352203