ACD Antibody, FITC conjugated

Cusabio

ACD Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

ACD

ACD shelterin complex subunit and telomerase recruitment factor

adrenocortical dysplasia homolog; adrenocortical dysplasia protein homolog; PIP1; POT1 and TIN2-interacting protein; PTOP; TIN2 interacting protein 1; TINT1; TPP1

Rabbit

IgG

Adrenocortical dysplasia protein homolog

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Human

-20°C or -80°C

12352203