Acetyl-Calpastatin(184-210)(human) [123714-50-1]

TargetMol Chemicals

Acetyl-Calpastatin(184-210)(human) [123714-50-1]

16

123714-50-1

Chemical

Acetyl-Calpastatin(184-210)(human)

C142H230N36O44S

3177.65

Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 microM). Increases secretion of amyoid beta-protein (Abeta) 42, Abeta40 and Abeta42 ratio.

3 years

C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C([C@H](CC(O)=O)NC(C)=O)=O)CCC3)CCSC)=O)CO)=O)CO)=O)[C@@H](C)O)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)[C@H](C)C)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)CCC1)N4[C@H](C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)=O)CCCCN)=O)CCC4

-20°C

12352200