AChE-IN-63 [876685-78-8]

TargetMol Chemicals

AChE-IN-63 [876685-78-8]

16

Research Use Only

C18H19N5O

321.38

AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 microM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 microM and 1.342 microM, respectively. AChE-IN-63 is effective in inhibiting Abeta aggregation and preventing the formation and deposition of Abeta1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimers disease [1].

N=1N=C(OC1C=2C=CC=CC2)CN3CCN(C4=NC=CC=C4)CC3

-20°C

51202000