AChE/BChE-IN-12

MedChem Express

AChE/BChE-IN-12

10

Research Use Only

C23H21N3O6

435.43

AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and beta-secretase-1 (BACE-1) inhibitor, with IC50 values of 2.57, 3.26, and 10.65 microM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-beta monomers. AChE/BChE-IN-12 can be used for Alzheimers disease (AD) research[1].

COC1=CC(CN2C=C(N=N2)COC3=C(C4=C(C=C3)C=CC(O4)=O)C(C)=O)=CC(OC)=C1

12131703