AChE/GSK-3beta-IN-1

MedChem Express

AChE/GSK-3beta-IN-1

10

Research Use Only

C31H35N7O3S

585.72

AChE/GSK-3beta-IN-1 (compound GT15) is a potent, dual AChE/GSK-3beta inhibitor with IC 50 values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3beta, respectively. AChE/GSK-3beta-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3beta-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3beta-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3beta-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3beta-IN-1 can be used for Alzheimers disease research [1] .

CNC(C(S1)=C(N=C1C2=CC(NC(CNCCNC3=C4CCCCC4=NC5=CC=CC=C35)=O)=NC=C2)OCC6CC6)=O

12352200