AChR alpha 4 antibody [N1C1]
GTX113653
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHamster, Human, Mouse
TargetCHRNA4
Overview
- SupplierGeneTex
- Product NameAChR alpha 4 antibody [N1C1]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.39 mg/ml
- ConjugateUnconjugated
- Gene ID1137
- Target nameCHRNA4
- Target descriptioncholinergic receptor nicotinic alpha 4 subunit
- Target synonymsBFNC; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; EBN; EBN1; NACHR; NACHRA4; NACRA4; neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha-4 subunit
- HostRabbit
- IsotypeIgG
- Protein IDP43681
- Protein NameNeuronal acetylcholine receptor subunit alpha-4
- Scientific DescriptionThis gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq]
- ReactivityHamster, Human, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Lowered levels of nicotinic acetylcholine receptors and elevated apoptosis in the hippocampus of brains from patients with type 2 diabetes mellitus and db/db mice. Xu Y et al., 2020 Jul 23, Aging (Albany NY)Read more
- Host cell tropism mediated by Australian bat lyssavirus envelope glycoproteins. Weir DL et al., 2013 Sep, VirologyRead more