Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ACO1 Polyclonal Antibody at dilution 1:50
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ACO1 Polyclonal Antibody at dilution 1:50
ACO1 Polyclonal Antibody
E-AB-12938
Product group Antibodies
Overview
- SupplierElabscience
- Product NameACO1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.4mg/ml
- Scientific DescriptionAconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5 UTR of ferritin mRNA, and in the 3 UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
- UNSPSC12352203