ACVR2A Polyclonal Antibody

Reddot Biotech

ACVR2A Polyclonal Antibody

5

Western Blot, ELISA

Research Use Only

Polyclonal

0.2 mg/ml

Unconjugated

ACVR2A

activin A receptor type 2A

activin A receptor, type IIA; activin receptor type-2A; ACTRII; ACVR2

Rabbit

IgG

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Human, Mouse, Rat

-20°C

12352203