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ProductsBack/ACY-775 [1375466-18-4]
Chemical Structure
Chemical Structure
Chemical Structure

ACY-775 [1375466-18-4]

Research Use Only
AG-CR1-3903
AdipoGen Life Sciences
CAS Number1375466-18-4
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight330.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    ACY-775 [1375466-18-4]
  • Delivery Days Customer
    10
  • CAS Number
    1375466-18-4
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C17H19FN4O2
  • Molecular Weight
    330.4
  • Scientific Description
    Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =7.5nM). Displays high selectivity over HDAC1-9 (IC50=1-10microM). Shows improved brain bioavailability compared to tubastatin A (Prod. No. AG-CR1-3900). Induces hyperacetylation of alpha-tubulin in brain without concurrently altering the acetylation of histones. Shows antidepressant activity. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration. - Chemical. CAS: 1375466-18-4. Formula: C17H19FN4O2. MW: 330.4. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =7.5nM). Displays high selectivity over HDAC1-9 (IC50=1-10microM). Shows improved brain bioavailability compared to tubastatin A (Prod. No. AG-CR1-3900). Induces hyperacetylation of alpha-tubulin in brain without concurrently altering the acetylation of histones. Shows antidepressant activity. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
  • SMILES
    ONC(=O)C1=CN=C(NC2(CCCCC2)C2=CC(F)=CC=C2)N=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC: S. Mithraprabhu, et al.; Br. J. Haematol. 162, 559 (2013)
  • Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer: J.S. Riley, et al.; Cell Death Dis. 4, e951 (2013)
  • RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth: K.A. Wilson-Edell, et al.; Oncotarget 5, 5165 (2014)
  • Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability: J. Jochems, et al.; Neuropsychopharmacol. 39, 389 (2014)