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Adagrasib

T8369
TargetMol Chemicals
CAS Number2326521-71-3
Product group Chemicals
Molecular Weight604.12
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Adagrasib
  • Delivery Days Customer
    4
  • CAS Number
    2326521-71-3
  • Category Supplier
    Chemical
  • Chemical Name
    Adagrasib
  • Molecular Formula
    C32H35ClFN7O2
  • Molecular Weight
    604.12
  • Scientific Description
    Adagrasib (MRTX849) is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. It selectively modifies mutant cysteine 12 in GDP-bound KRASG12C, and inhibits KRAS-dependent signaling.
  • Shelf life instruction
    3 years
  • SMILES
    O(C[C@@H]1CCCN1C)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5Cl)=N2)N6C[C@H](CC#N)N(C(C(=C)F)=O)CC6
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Jay B Fell , John P Fischer , Brian R Baer.Identification of the Clinical Development Candidate MRTX849, a Covalent KRAS G12C Inhibitor for the Treatment of Cancer.J Med Chem. 2020 Apr 6.