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ADAMTSL2 antibody [C3], C-term

GTX102069
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetADAMTSL2
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Overview

  • Supplier
    GeneTex
  • Product Name
    ADAMTSL2 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9719
  • Target name
    ADAMTSL2
  • Target description
    ADAMTS like 2
  • Target synonyms
    ADAMTSL-2; ADAMTS-like protein 2; GPHYSD1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ86TH1
  • Protein Name
    ADAMTS-like protein 2
  • Scientific Description
    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The Transcriptional Landscapes and Key Genes in Brain Arteriovenous Malformation Progression in a Venous Hypertension Rat Model Revealed by RNA Sequencing. Li S et al., 2022, J Inflamm Res
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  • Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking. Piccolo P et al., 2019 Dec, Mol Genet Metab Rep
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  • Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families. Aviram R et al., 2019 Jan, Matrix Biol
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  • Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia. Hubmacher D et al., 2015 May, Dis Model Mech
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