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ADAMTSL2 antibody [C3], C-term detects ADAMTSL2 protein at cytosol(secreted) on SkHep1xenograft by immunohistochemical analysis. Sample: Paraffin-embedded SkHep1xenograft. ADAMTSL2 antibody [C3], C-term (GTX102069) dilution: 1:500. Antigen Retrieval: Trilogy? (EDTA based, pH 8.0) buffer, 15min
ADAMTSL2 antibody [C3], C-term detects ADAMTSL2 protein at cytosol(secreted) on SkHep1xenograft by immunohistochemical analysis. Sample: Paraffin-embedded SkHep1xenograft. ADAMTSL2 antibody [C3], C-term (GTX102069) dilution: 1:500. 
 Antigen Retrieval: Trilogy? (EDTA based, pH 8.0) buffer, 15min
ADAMTSL2 antibody [C3], C-term detects ADAMTSL2 protein at cytosol(secreted) on SkHep1xenograft by immunohistochemical analysis. Sample: Paraffin-embedded SkHep1xenograft. ADAMTSL2 antibody [C3], C-term (GTX102069) dilution: 1:500. Antigen Retrieval: Trilogy? (EDTA based, pH 8.0) buffer, 15min

ADAMTSL2 antibody [C3], C-term

GTX102069
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetADAMTSL2
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Overview

  • Supplier
    GeneTex
  • Product Name
    ADAMTSL2 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9719
  • Target name
    ADAMTSL2
  • Target description
    ADAMTS like 2
  • Target synonyms
    ADAMTSL-2, GPHYSD1, ADAMTS-like protein 2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ86TH1
  • Protein Name
    ADAMTS-like protein 2
  • Scientific Description
    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Li S, Tao W, Huang Z, et al. The Transcriptional Landscapes and Key Genes in Brain Arteriovenous Malformation Progression in a Venous Hypertension Rat Model Revealed by RNA Sequencing. J Inflamm Res. 2022,15:1381-1397. doi: 10.2147/JIR.S347754
    Read this paper
  • Piccolo P, Sabatino V, Mithbaokar P, et al. Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking. Mol Genet Metab Rep. 2019,21:100504. doi: 10.1016/j.ymgmr.2019.100504
    Read this paper
  • Aviram R, Zaffryar-Eilot S, Hubmacher D, et al. Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families. Matrix Biol. 2019,75-76:114-125. doi: 10.1016/j.matbio.2018.05.003
    Read this paper
  • Hubmacher D, Wang LW, Mecham RP, et al. Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia. Dis Model Mech. 2015,8(5):487-99. doi: 10.1242/dmm.017046
    Read this paper